STRs database » MIR7-2 locus

Gene	MIR7-2
Location	Intergenic in 15q26.1
Reference region	chr15:88569436-88569452 (hg38) chr15:89112667-89112683 (hg19) chr15:86324041-86324057 (hs1)
Repeat unit	TTTG
Repeat type	Standard

Distribution of repeats in a superpopulation

Population data for this locus is not available yet.

→ View repeat distributions in gnomAD database

Overview of repeats

Grasberger et al. (2024) identified mutations in an intergenic (TTTG)4 repeat in 82 affected individuals from 12 families with dominantly inherited thyrotropin resistance. The variants included a one-unit contraction or a sequence change and activated a thyroid-specific enhancer associated with increased MIR7-2/MIR1179 expression. Narumi et al. (2024) independently identified disease-associated variation at the same microsatellite in families with nonautoimmune thyroid abnormalities.

Disease(s) and range of repeats

Disease	Onset	Inheritance	Normal	Intermediate	Pathogenic
Congenital hypothyroidism, nongoitrous, 3 (CHNG3)	Congenital / variable	Autosomal dominant	4	-	= 3